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CHARLOTTE, N.C., July 17, 2013 (GLOBE NEWSWIRE) — Chelsea Therapeutics International, Ltd. (Nasdaq:CHTP) today appear that the U.S. Food and Biologic Administration (FDA) has accustomed cancellation of the New Biologic Application (NDA) resubmission gluttonous approval to bazaar NORTHERA™ (droxidopa), an orally alive constructed forerunner of norepinephrine, for the analysis of appropriate neurogenic orthostatic hypotension (NOH) in patients with primary autonomic abortion (Parkinson’s disease, assorted arrangement decline and authentic autonomic failure), dopamine beta hydroxylase absence and non-diabetic autonomic neuropathy. The FDA has accounted the resubmission a complete acknowledgment to its March 28, 2012 Complete Acknowledgment Letter and assigned a new Prescription Biologic User Fee Act (PDUFA) ambition date of January 3, 2014.

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“Northera holds the abeyant to serve as an important new ameliorative advantage for patients active with the debilitating furnishings of NOH,” said Joseph G. Oliveto, Interim Chief Executive Officer of Chelsea. “FDA accepting of the abyss of our NDA resubmission is addition key anniversary in extensive this goal. We will abide to assignment carefully with the FDA against an approval accommodation for Northera by aboriginal abutting year, and beforehand our bartering action in apprehension of a U.S. bartering barrage anon afterwards this.”

Northera was ahead accepted Orphan Biologic Appellation and accustomed Fast Track appellation from the FDA. Fast Track appellation is advised to facilitate the analysis of articles that abode austere or potentially life-threatening altitude for which there is an unmet medical need.

About Appropriate NOH

NOH is a abiding neurogenic ataxia consistent from amiss absolution of norepinephrine that predominantly affects patients with primary autonomic failure, a accumulation of diseases which includes Parkinson’s ache (PD), assorted arrangement decline (MSA) and authentic autonomic abortion (PAF). Symptoms of NOH include: dizziness, lightheadedness, blurred vision, fatigue, poor concentration, and amazement episodes back a being assumes a continuing position, generally acutely attached a person’s adeptness to accomplish accepted circadian activities that crave continuing or walking for both abbreviate and continued periods of time.

About Northera

NORTHERA™ (droxidopa), the advance investigational abettor in Chelsea Therapeutics’ pipeline, is currently in Phase III development for the analysis of appropriate neurogenic orthostatic hypotension (NOH) in patients with primary autonomic abortion — an adumbration that includes a cogent cardinal of patients with Parkinson’s disease, assorted arrangement decline (MSA) and authentic autonomic abortion (PAF).  Droxidopa is a constructed catecholamine that is anon adapted to norepinephrine (NE) via decarboxylation, consistent in added levels of NE in the afraid system, both centrally and peripherally.

Droxidopa, developed by and accountant from Dainippon Sumitomo Pharma Co., Ltd. (DSP), initially accustomed Japanese approval in 1989 for the analysis of arctic amble and blackout on continuing associated with Parkinson’s Ache and for the analysis of orthostatic hypotension, blackout or blackout on continuing associated with Shy-Drager affection and Familial Amyloidotic Polyneuropathy. In 2000, Droxidopa accustomed broadcast business approval to accommodate blockage of vertigo, blackout and weakness associated with orthostatic hypotension in hemodialysis patients.

About Chelsea Therapeutics

Chelsea Therapeutics (Nasdaq:CHTP) is a biopharmaceutical development aggregation that acquires and develops avant-garde articles for the analysis of a array of animal diseases, including axial afraid arrangement disorders.  Chelsea is currently advancing FDA approval in the U.S. for Northera™ (droxidopa), a novel, late-stage, orally-active ameliorative abettor for the analysis of appropriate neurogenic orthostatic hypotension in patients with primary autonomic failure.  For added advice about the Company, appointment

This columnist absolution contains advanced statements apropos approaching contest including our ambition to accompany the development of Northera. These statements are accountable to risks and uncertainties that could account the absolute contest or after-effects to alter materially. These accommodate assurance on key cadre and our adeptness to allure and/or absorb key personnel; the accident that FDA will not accede that our analytic balloon after-effects authenticate the assurance and capability of droxidopa; the accident that the FDA will not acquire our angle apropos any balloon or added abstracts to abutment a new biologic application; the accident that the FDA will not accept the resubmitted NDA; the accident that our assets will not be adequate to conduct any abstraction of Northera that will be adequate to the FDA; the accident that we cannot complete any added abstraction for Northera after the charge for added capital; the risks and costs of biologic development and that such development may booty best or be added big-ticket than anticipated; our charge to accession added operating basic in the future; our assurance on our advance biologic applicant droxidopa; accident that we will not be able to access authoritative approvals of droxidopa or our added biologic candidates for added indications; accident of animation in our banal price, accompanying litigation, and analyst advantage of our stock; assurance on collaborations and licenses; bookish acreage risks; our history of losses; competition; bazaar accepting for our articles if any are accustomed for marketing.

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