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GeoVax Continues Expansion of International Collaborative Efforts for its Different MVA-VLP Vaccine Technology
ATLANTA, GA, Nov. 13, 2018 (GLOBE NEWSWIRE) — via NEWMEDIAWIRE — GeoVax Labs, Inc. (OTCQB: GOVX), a biotechnology aggregation developing beastly vaccines, and Virometix AG, a aggregation developing next-generation Constructed Virus-Like Particle (SVLPTM) based vaccines, appear today the alpha of a accord to advance a ameliorative vaccine for beastly papillomavirus (HPV) infection. The accord will accommodate preclinical beastly testing of GeoVax’s MVA-vectored HPV vaccine candidates in aggregate with Virometix’ constructed HPV vaccine candidate.
GeoVax’s vaccine technology is based on its alive Modified Vaccinia Ankara (MVA) platform, which generates vaccine antigens, in the anatomy of multimeric proteins or noninfectious VLPs, in the alone actuality vaccinated. Gene sequences of ambition antigens are amid into the MVA genome which drives their announcement and beginning from the adulterated cells. In this way, anesthetic induces two pools of antigens as targets for the allowed acknowledgment – virus-infected beef and appear multimeric or VLP proteins. This action mimics a accustomed viral infection, triggering the anatomy to aftermath a able-bodied and abiding allowed acknowledgment with captivation of both antibodies and T cells.
Farshad Guirakhoo, PhD, GeoVax’s Chief Scientific Officer, commented, “This new accord altogether complements our advancing accord with Emory University for HPV-related arch and close cancers in patients who accurate oncogene articles of HPV16, E6 and E7 proteins. Similar to the action we are utilizing in our analytic trials for HIV and preclinical testing of our blight vaccines (e.g. agent and protein combination), we accept the aggregate of our MVA-vectored HPV vaccines and Virometix’ SVLP-based HPV vaccine will accompany a synergy that decidedly increases the ameliorative abeyant of anniversary platform. This and added collaborations that we’ve accustomed and abide to establish, are focused on accouterment alarmingly bare solutions to either anticipate or cure analytical areas of communicable diseases and cancers utilizing our different ability and know-how, consistent in awful effective, safe, simple to administrate and bargain bogus solutions, convalescent the lives of millions worldwide.”
“We are admiring to access into this collaboration, which will aggrandize our charge to the development of blight immunotherapies,” said Arin Ghasparian, PhD, Virometix’ Chief Executive Officer. “We acknowledge the analytic and preclinical development assignment done by GeoVax on their vaccine candidates for viral diseases and cancer. We accept that a aggregate of MVA-vectored HPV vaccine candidates with our SVLPTM belvedere could be potentially amiable for the immunotherapy of HPV-induced cancers and attending advanced to alive with GeoVax on this combination.”
HPV refers to a accumulation of added than 200 accompanying viruses. Added than 40 bacilli can calmly be absolved through animal contact, admitting added types can account animal warts that are not ually transmitted. Sexually transmitted HPV are classified into 2 categories; Low accident HPV (e.g. blazon 6 and 11) that account amiable tumors and high-risk HPV (e.g. blazon 16 and 18) that account cancers (e.g. cervical, anal, penile and oropharyngeal). Every year in the United States, there are an estimated 14 actor new HPV infections, with about 50% occurring in 15 to 24-year-olds. Currently, there are an estimated 79 actor Americans, best in their backward adolescence and aboriginal 20s, adulterated with HPV. In fact, HPV is so accepted that it infects about all men and women at some point in their lives, but fortunately, in best cases, HPV infections are asymptomatic and do not account any bloom problems. However, in some instances, HPV can account bloom problems like animal warts and cancer. Although there are vaccines that can anticipate infections with the types of HPV that best frequently account cancer, there is currently no cure for an HPV infection afterwards it has accustomed in a person.
Virometix AG is a abreast captivated biotechnology aggregation developing a new bearing of absolutely constructed vaccines and immunotherapeutic drugs for the blockage and analysis of communicable diseases and cancer. Fast growing demands, bloom threats from anew arising circuitous viral and bacterial bacilli and added acrimonious requirements for stability, assurance and tolerability crave new approaches to arrest accepted and approaching challenges. Rational atomic design, and Virometix’ proprietary “Synthetic Virus-Like Particle” (SVLPTM) and “Synthetic Antigen Mimetics” (SAMTM) platforms acquiesce for the accelerated assembly and access of vaccine candidates with above backdrop in agreement of safety, ability and stability. Virometix is based in Zurich, Switzerland. For added advice about Virometix AG amuse visit: https://www.virometix.com/.
GeoVax Labs, Inc., is a clinical-stage biotechnology aggregation developing beastly vaccines adjoin communicable diseases application its MVA-VLP vaccine platform. GeoVax was the champ of the 2018 “Best Biotech” Vaccine Industry Excellence Awards, a finalist for the 2018 “Best Prophylactic Vaccine” Award for its Zika vaccine at the World Vaccine Congress, as able-bodied as a finalist for Pipelines of Promise at Buzz of Bio 2018. The Company’s development programs are focused on vaccines adjoin HIV, Zika, hemorrhagic agitation bacilli (Ebola, Sudan, Marburg, Lassa) and malaria. GeoVax additionally is evaluating the use of its MVA-VLP belvedere in blight immunotherapy, and for ameliorative use in abiding Hepatitis B infections. GeoVax’s vaccine belvedere supports in vivo production of non-infectious VLPs from the beef of the very person accepting the vaccine. The assembly of VLPs in the actuality actuality vaccinated mimics virus assembly in a accustomed infection, aesthetic both the humoral and cellular accoutrements of the allowed arrangement to recognize, prevent, and ascendancy the ambition infection. For added information, visit www.geovax.com.
Certain statements in this certificate are “forward-looking statements” aural the acceptation of the Private Securities Litigation Reform Act. These statements are based on management’s accepted expectations and are accountable to ambiguity
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